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in Nov. 2005 i went on minocycline 100mg BID, as a 2005 study indicated that it fights HIV in the brain better than HAART. as of 2010, there's evidence it suppresses the activation of dormant t-cells infected with HIV, w/o doing so to uninfected t-cells. look up minocycline in wikipedia for more info. sidefx include darker (more sun-sensitive) and clearer skin than my siblings, and never testing poz for syphilis or gonorrhea...but it lowers blood levels of Reyataz, and possibly other drugs.
I'm not trying to discredit the paper, but macrophages are CD4+, they just have them in lower amounts that CD4+ Tcells and the article actually says that. This "finding" isn't anything new, it is a known fact that different compartments in the body (such as gut, CSF, blood)are inhibited by slightly different strains of HIV, which is just a microscopic effect of evolution (adaptation to different environments)
I believe CNS should actually be CSF... CNS isn't defined in the article.
Ive said it before, bit225 in phase 2a trials now by the australian biotron company is the most promising curative candidate thus far. It attacked the vpu protein of hiv which stops it hiding and also attacks hiv in macrophages. For some reason this promising drug seems to be completely off all hiv website news radar, ive known about it since 2009 or so.
This seems to suggest that HAART is beneficial but that it works much more slowly on virus that has infected macrophages. Therefore, starting therapy early and starting the long decay process in the CNS could be very important regardless of CD4 and viral load counts in the blood.
talk about depressing news. wow. this is devastating. i am very sad that there's nothing even close in this report pointing to ANY remedy. A sad day. To hell with this Disgusting virus I hate it and I hate the slow 'progress' with all this research.
Can someone explain the last sentence to me? Treatment doesn't seem to do jack for cognitive issues. If someone finds out that HIV was replicating independently in their CNS, it seems almost cruel to preserve the person for dementia.
tboyinhouston
I am diagnosed with "memory lapses likely due to HIV infection". I am getting worse by the year. I went off meds for about a year and I regret this decision because it seems that my memory problems began after that. I do not recommend anyone stop meds for any reason because of my experience. My second neuropsych test indicates further decline and my neurologist suspects that what is written in this article happened to me.
October 20, 2011