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People who switched from tenofovir disoproxil fumarate to tenofovir alafenamide gained weight regardless of other meds.
The global supply of tenofovir and six other important generic drugs must be ensured, warns a UNAIDS analysis.
Researchers compared the demographics of participants in randomized controlled trials for antiretrovirals with the global HIV population.
Tenofovir alafenamide is an updated version of tenofovir disoproxil fumarate that is tied to better bone and kidney health.
The observation that there have been Covid-19 infections in HIV+ persons on TDF/TAF argues against a complete protection from these agents.
Studies have found that weight gain is common after people with HIV begin an antiretroviral in this class.
Newer drug classes are tied to a higher risk of weight gain, which is more likely to occur among Black women in particular.
Switching to new tenofovir tied to improved bone health in older people with HIV
Both Truvada and Descovy are highly effective and safe for most people taking PrEP, but the newer option has more cost barriers.
Researchers have called for revised treatment guidelines to address the higher risk of fracture in the HIV population.
Learn about the differences between these two HIV prevention options.
Future research should examine how particular combinations of antiretrovirals contribute to weight gain, according to one expert.
Participants entered the study taking tenofovir disoproxil fumarate, and some were switched to a regimen including tenofovir alafenamide.
The integrase inhibitor–based HIV regimen was compared with dolutegravir-based regimens.
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