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Certain drugs in this class may increase the likelihood of diabetes and hypertension, but cardiovascular risk factors can be managed.
Research on the links between tenofovir and other antiretrovirals, SARS-CoV-2 infection and COVID severity has produced mixed results.
In the 1980s, AZT was labeled the most expensive drug in history at $8,000 annually. Now, scores of drugs cost more than $50,000 a year.
At three years, median height and bone mineral density were similar for children with and without tenofovir exposure in the womb.
Internal documents show Gilead held off on developing new therapies, such as Descovy, a potentially less toxic version of Truvada.
TDF/FTC is effective for cisgender women who take at least four pills per week, but many struggle to reach this level of adherence.
Disruption of fat metabolism and altered gut microbiome may help explain weight changes associated with antiretroviral therapy.
Several mechanisms may play a role, including persistent virus and ongoing immune dysregulation.
Changes in kidney function were small for those using TDF/FTC either daily or on-demand for HIV prevention.
Switching from TAF to TDF may help people lose weight, but this must be balanced against the risk of kidney problems and bone loss.
The updated guidance says antiretroviral therapy should be started as soon as possible after diagnosis and outlines the latest options.
Although 71% of survey respondents were aware of PrEP, just 19% had ever used HIV prevention pills.
Research on links between tenofovir, SARS-CoV-2 infection and COVID severity have yielded mixed results, but new study suggests it helps.
Children born to mothers on PrEP appeared to have normal growth and cognitive development.
The prevention pills—and newer methods—have averted countless HIV cases, but they still aren’t reaching everyone who could benefit.
The PrEP 2-1-1 regimen offers an option to take HIV prevention pills before and after sex instead of every day.
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