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People who switched from tenofovir disoproxil fumarate to tenofovir alafenamide gained weight regardless of other meds.
The global supply of tenofovir and six other important generic drugs must be ensured, warns a UNAIDS analysis.
Researchers project the Brazilian man could become the first person deemed cured of HIV without a bone marrow transplant.
Tenofovir alafenamide is an updated version of tenofovir disoproxil fumarate that is tied to better bone and kidney health.
The observation that there have been Covid-19 infections in HIV+ persons on TDF/TAF argues against a complete protection from these agents.
Studies have found that weight gain is common after people with HIV begin an antiretroviral in this class.
Switching to new tenofovir tied to improved bone health in older people with HIV
Both Truvada and Descovy are highly effective and safe for most people taking PrEP, but the newer option has more cost barriers.
Researchers have called for revised treatment guidelines to address the higher risk of fracture in the HIV population.
Learn about the differences between these two HIV prevention options.
Future research should examine how particular combinations of antiretrovirals contribute to weight gain, according to one expert.
Participants entered the study taking tenofovir disoproxil fumarate, and some were switched to a regimen including tenofovir alafenamide.
The integrase inhibitor–based HIV regimen was compared with dolutegravir-based regimens.
However, serious kidney problems and bone fractures were rare among people taking either Descovy or Truvada for HIV prevention.
This finding from a study of people switching from TDF to TAF for HIV treatment may also have implications for those on PrEP.
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