People are talking, and what they want to know is “If my CD4s go above 200 on HAART, can I quit my PCP prophylaxis?” It may not be that easy, according to new findings reported by John Mellors, MD, and his colleagues. Using the time-honored Multicenter AIDS Cohort Study data, they found that in those with CD4 counts above 200 and viral loads over 30,000, the incidence of PCP was equal to or greater than that seen in those with counts below 200 and viral loads below 30,000. Mellors proposes that all patients with viral loads above 30,000—regardless of CD4 count—protect themselves against PCP.