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Study findings shed light on possible causes of long COVID and could lead to more sensitive testing and personalized treatments.
The findings provide a basis for future studies of the immune system’s role in longevity.
NIH-funded study suggests need to boost CD8+ T cell response after infection.
Overall, people with and without HIV had low and comparable rates of severe breakthrough illness.
Older people, immunocompromised people and those with underlying health conditions can benefit most from additional shots.
HIV mutates rapidly, enabling the virus to evade the common, narrowly targeted antibodies produced by most people with HIV.
Researchers showed that B cells evolve after COVID-19 vaccination to help improve protection against SARS-CoV-2 over time.
The experimental vaccine regimen aims to train B cells to produce broadly neutralizing antibodies against HIV.
The findings suggest boosters not only lengthen immunity but help broaden and strengthen the immune response.
The findings could have implications for vaccines against other rapidly evolving pathogens, such as influenza virus or SARS-CoV-2.
People who received the Moderna COVID-19 vaccine had strong immune memory of SARS-CoV-2 six months after vaccination.
Response to natural SARS-CoV-2 infection suggests HIV-positive people can also respond well to COVID-19 vaccines.
Two experimental vaccine approaches, using mRNA protein delivery and germline targeting, are in the early stages of development.
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