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While not cured, the man has maintained viral suppression for more than two decades after stopping antiretroviral therapy.
The first three people who received the experimental therapy experienced no serious adverse effects or toxicities.
Two of 11 people who received four doses of budigalimab maintained viral suppression for a year and a half after stopping antiretrovirals.
Latently infected cells continue to produce viral RNA and proteins, and even defective HIV can trigger persistent immune activation.
The man, who was diagnosed with HIV in 1990, received chemotherapy and radiation followed by a stem cell transplant in July 2018.
Experimental gene therapy excises HIV-like virus from infected cells in monkeys.
Potential cure strategy builds on unexpected findings about hematopoietic stem cells.
Ruxolitinib might have contributed to a functional cure after a stem cell transplant without a rare mutation.
Researchers preview studies on circumcision, PrEP for women, mpox, COVID-19 and HIV functional cure.
A new case raises questions about the keys to success for a functional cure after a stem cell transplant.
44% of children treated with two bnAbs maintained viral suppression after stopping antiretrovirals.
HIV-positive people who use checkpoint inhibitors have side effects, response rates and survival comparable to those of HIV-negative people.
The experimental vaccine regimen trains the immune system to produce broadly neutralizing antibodies that target HIV.
Marc Franke is part of an exclusive circle of people cured of HIV after a stem cell transplant to treat cancer.
Gene therapy that alters CCR5 receptors and excises HIV from infected cells eliminated the virus in mice.
This may help expand the pool of available stem cells for curing HIV in people who require transplants for other medical conditions.
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