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Two drugs widely used to treat certain autoimmune diseases substantially improved clinical status and reduced deaths.
Over half of people with HIV and 17% of those newly diagnosed are 50 and older.
Protecting the immunocompromised is not only a matter of health equity, it’s critical to ending the pandemic.
Researchers showed that B cells evolve after COVID-19 vaccination to help improve protection against SARS-CoV-2 over time.
Boosters reduced the risk of hospitalization and death by about 80% for people with HIV, cancer, autoimmune conditions or organ transplants.
Older and immunocompromised people and those with underlying health conditions could benefit most from additional shots.
The findings suggest boosters not only lengthen immunity but help broaden and strengthen the immune response.
People who received the Moderna COVID-19 vaccine had strong immune memory of SARS-CoV-2 six months after vaccination.
About half of people hospitalized with COVID-19 had antibodies that could mistakenly attack the body’s own proteins and tissues.
The booster is recommended for organ transplant recipients, people receiving cancer treatment and people with advanced or untreated HIV.
Experts call for heightened precautions and better, more intensive therapies for COVID-19 patients with weakened immune systems.
Response to natural SARS-CoV-2 infection suggests HIV-positive people can also respond well to COVID-19 vaccines.
People with immune deficiency may not respond as well to vaccines but could still gain some protection.
Research suggests protective effect of natural infection or vaccination is likely to be persistent.
Natural immunity and vaccine responses may be weaker in people with immune suppression, so they should get their second dose promptly.
Long-lived memory immune cells continue to provide protection even after antibody levels drop.
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