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A mid-stage trial showed the combo suppressed HIV, was well tolerated and resulted in a low rate of virologic failure.
Merck’s experimental HIV drug proves effective and well tolerated
These medications can now be used by people on stable antiretroviral treatment with undetectable viral load.
This finding did not vary based on the dose of the nucleoside reverse transcriptase translocation inhibitor, formerly called MK-8591.
An OK would add an indication for the use of these HIV medications among those switching from stable regimens.
Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate) includes Pifeltro (doravirine) in a three-drug single-tablet regimen.
Compared with a regimen based on Prezista, doravirine was better for blood lipids, including cholesterol and triglycerides.
The new drug application is for doravirine as both an individual tablet and part of a combination tablet.
The new single-tablet NNRTI regimen was less likely than Atripla to cause neurological symptoms.
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