Generic Name: dolutegravir + rilpivirine
Abbreviation: DTG + RPV
Other Market Name: N/A
Drug Class: Single-Tablet Regimens
Company: ViiV Healthcare and Janssen Therapeutics
Approval Status: Approved
Generic Version Available: No
Experimental Code: N/A
Juluca has not yet been reviewed for inclusion in the DHHS list of recommended HIV treatments. Visit https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/0 for the full DHHS guidelines.
Juluca is a single-tablet regimen for HIV. It contains two different HIV drugs: an approved integrase inhibitor (dolutegravir) and an approved non-nucleoside reverse transcriptase inhibitor (rilpivirine). Juluca was approved by the U.S. Food and Drug Administration in November 2017.
Juluca was developed as two-drug “maintenance therapy” for people living with HIV. It can be used in place of a regimen involving three or more drugs, but only for those who have undetectable viral loads while on a stable HIV drug regimen for at least six months. Additionally, Juluca should only be used by those with no history of HIV treatment failure and no known HIV mutations known to cause resistance to either dolutegravir or rilpivirine.
Adult Dose: One tablet once a day. Each tablet contains 50mg dolutegravir + 25mg rilpivirine. Juluca must be taken with a meal (with breakfast or dinner, for example).
Pediatric Dose: N/A
Dosing Info: This is a complete one-pill, once-daily drug regimen. It must be taken with a meal.
The most common adverse health events among those taking Juluca were diarrhea and headache.
For a review of drug interactions, including prescription and over-the-counter medications and supplements that should not be taken with Juluca or may require dose adjustments, consult the Juluca package insert.
Before taking this medication, tell your doctor if you have kidney disease, liver disease (including hepatitis B), or a history of depression/suicidal thoughts. In addition, tell your doctor if you are pregnant or planning to become pregnant, if you are breast feeding, and all your medical conditions, including all prescription and over-the-counter medications and supplements you are taking.
Last Revised: November 21, 2017