Generic Name: dolutegravir + rilpivirine

Pronunciation: N/A

Abbreviation: DTG + RPV

Other Market Name: N/A

Drug Class: Single-Tablet Regimens

Company: ViiV Healthcare and Janssen Therapeutics

Approval Status: Experimental

Generic Version Available: No

Experimental Code: N/A

Drug Recommendation

DTG + RPV has not yet been reviewed for inclusion in the DHHS list of recommended HIV treatments.

General Info

DTG + RPV is an experimental HIV medication. It contains an approved integrase inhibitor and an approved non-nucleoside reverse transcriptase inhibitor. It is currently in Phase III clinical trials.

DTG+ RPV is a single-tablet regimen containing two currently approved HIV medications (dolutegravir and rilpivirine). It is being developed as two-drug “maintenance therapy” for people living with HIV. In clinical trials, study participants must first decrease their viral loads to undetectable levels using a three-drug treatment regimen before switching to the two-drug single-tablet regimen.


Adult Dose: One tablet once a day. Each tablet contains 50mg dolutegravir + 25mg rilpivirine.

Pediatric Dose: N/A

Dosing Info: This is a complete one-pill, once-daily drug regimen.

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Other Info


Last Revised: September 5, 2017