Generic Name: Ibalizumab
Drug Class: Entry Inhibitors
Company: TaiMed Biologics and Theratechnologies
Approval Status: Approved
Generic Version Available: No
Experimental Code: TMB-355
The U.S. Department of Health and Human Services (DHHS) Panel on Antiretroviral Guidelines for Adults and Adolescents says that people with ongoing detectable viral load who lack sufficient treatment options to construct a fully suppressive regimen may be candidates for Trogarzo. Trogarzo is generally reserved for treatment-experienced people with drug-resistant HIV. Visit http://aidsinfo.nih.gov/contentfiles/lvguidelines/aa_recommendations.pdf for the full DHHS guidelines.
Trogarzo is an HIV medication. It was approved by the U.S. Food and Drug Administration for use by people living with HIV in March 2018. Trogarzo is an HIV entry inhibitor. It contains genetically engineered antibodies, known as monoclonal antibodies, that bind to the CD4 receptor on CD4 cells. Once they do this, HIV cannot successfully latch onto these cells, thus preventing the virus from infecting them.
Trogarzo, an injectable biologic, was developed specifically for people living with HIV whose virus is resistant to currently approved antiretrovirals. It needs to be combined with oral antiretrovirals, preferably HIV medications to which the virus is still at least partly sensitive. Drug-resistance testing is very important in figuring out which antiretrovirals to combine with Trogarzo.
Adult Dose: Trogarzo is administered intravenously (IV) as a single loading (or initial) dose of 2,000 mg followed by a maintenance dose of 800 mg every two weeks.
Pediatric Dose: N/A
Dosing Info: NA
Common side effects associated with Trogarzo-based regimens include diarrhea, dizziness, nausea and rash.
Trogarzo can cause serious side effects, including changes in your immune system (Immune Reconstitution Inflammatory Syndrome), which can happen when you start taking HIV-1 medicines. Tell your health care provider right away if you start having new symptoms after starting Trogarzo.
For a review of drug interactions, including prescription and over-the-counter medications and supplements that should not be taken with Trogarzo or may require dose adjustments, consult the Trogarzo package insert.
Before taking this medication, tell your doctor if you are pregnant or planning to become pregnant, if you are breastfeeding, and all your medical conditions, including all prescription and over-the-counter medications and supplements you are taking.
For More Info: http://trogarzo.com/
Last Reviewed: May 21, 2019