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Potential cure strategy builds on unexpected findings about hematopoietic stem cells.
Marc Franke is part of an exclusive circle of people cured of HIV after a stem cell transplant to treat cancer.
Gene therapy that alters CCR5 receptors and excises HIV from infected cells eliminated the virus in mice.
This may help expand the pool of available stem cells for curing HIV in people who require transplants for other medical conditions.
Adam Castillejo, aka the London Patient, continues to advocate for a widely applicable HIV cure.
She has not experienced viral rebound and tests negative for HIV antibodies.
One new approach protects CD4 cells against HIV entry, while another snips out viral genes in infected cells.
Researchers are surprised and concerned that a strain of HIV that is so broadly resistant to treatment even has the capacity to transmit.
Researchers hope to combine gene editing with a less toxic stem cell transplant. Findings may apply to cancer and other illnesses.
The researcher used CRISPR/Cas9 technology to render a pair of twins resistant to HIV.
CCR5-blocking antibody leads to long-term HIV suppression
Interfering with this receptor on immune cells could have harmful health consequences.
A second man’s virus went into remission following an HIV-resistant stem cell transplant to treat his cancer.
Two gene-editing experts said Jiankui He’s actions were a “gross violation” of Chinese regulations and international standards.
“The Düsseldorf Patient” has been off HIV meds only since November 2018, so it is much too early to determine whether he has been cured.
Researchers think a more efficient means of modifying immune cells to resist the virus could yield a stronger effect.
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